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YIR-819 TFA salt
CAS No. 1883372-87-9
YIR-819 TFA salt( YIR819 )
Catalog No. M12923 CAS No. 1883372-87-9
YIR-819 is a small-molecule CD4 mimic that acts as a highly potent HIV entry inhibitor with IC50 of 2.6 uM against YTA48P virus with no significant cytotoxicity (CC50=33 uM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameYIR-819 TFA salt
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NoteResearch use only, not for human use.
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Brief DescriptionYIR-819 is a small-molecule CD4 mimic that acts as a highly potent HIV entry inhibitor with IC50 of 2.6 uM against YTA48P virus with no significant cytotoxicity (CC50=33 uM).
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DescriptionYIR-819 is a small-molecule CD4 mimic that acts as a highly potent HIV entry inhibitor with IC50 of 2.6 uM against YTA48P virus with no significant cytotoxicity (CC50=33 uM); A useful lead compound for the further development of HIV-1 entry inhibitors and could potentially be useful for co-administration with neutralizing antibodies for the treatment of HIV infection and AIDS.
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In Vitro——
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In Vivo——
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SynonymsYIR819
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PathwayMicrobiology/Virology
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TargetHIV
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RecptorHIV
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Research Area——
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Indication——
Chemical Information
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CAS Number1883372-87-9
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Formula Weight606.044
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Molecular FormulaC25H35ClF3N7O5
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical NameN1-(4-chlorophenyl)-N2-(1-(2-(2-guanidinoacetamido)ethyl)-1-azaspiro[5.5]undecan-4-yl)oxalamide TFA salt
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Ohashi N, et al. ChemMedChem. 2016 Apr 19;11(8):940-6.
2. Boonstra A, et al. Antivir Ther. 2012;17(4):657-67.
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